VDR is a gene that encodes a protein that acts as a receptor for vitamin D, which regulates bone development and calcium absorption. A variant of https://www.gescheftmarketing.de/ the gene, the rs2228570 (FokI polymorphism) is associated with a decrease in bone mineral density in white prepubescent girls.

The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is regulated by the reciprocal and temporal pattern of on- and off occupancy of the VDRE by two components, and is influenced by chromosomal location and binding preferences for certain hormones. Microarray studies of human cells show that more than 100 genes carry a distinct VDRE located in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.

A virtual data room (VDR) is an online repository of data and documents related to business, legal transactions or other activities that have limitations on viewing and downloading. It utilizes a central server and an extranet connection which is an Internet connection with restricted access, to offer controlled access to users at specific intervals during which users can access the data and documents.

Companies that deal with investment bankers and in mergers and acquisitions are among the most common users of a VDR. They need to be able to communicate information in a clear manner with potential investors and buyers. Due diligence processes can also require a large amount of information. Life science companies also use VDRs for everything from clinical trial results to HIPAA compliance documentation.